目次 at IgMin Research

Synthetic approaches to the construction of the heterocyclic benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidine system based on heterocyclizations of substituted benzimidazoles and a new alternative strategy based on 2,4,6-trisubstituted pyrimidinyl-5-propanoic acids are considered. The latter method has been shown to be a successful addition to previously described methods, since it allows one to bypass the significant limitations associated with the use of substituted benzimidazoles and allows the introduction of fu...nctional substituents at different positions of the heterocycle that are inaccessible by other methods. The available information on derivatives of this heterocyclic system and their biological properties is summarized.Read more

This research reveals the previously unexplored pharmacognostic potential of antidepressants found in nutrients derived from both legume and animal sources. Through preclinical investigations involving mouse models, the study focused into antidepressant and antioxidant activities of non-denatured and denatured protein extracts from beans and eggs. Non-denatured protein extracts from beans and eggs, at saturation levels of 40% and 80%, were examined as macronutrients, while denatured protein extracts at equivalent saturation levels were consider...ed micronutrients. The study employed the DPPH and hydrogen peroxide tests to assess antioxidant activity, and the forced swimming test and sucrose preference test to evaluate acute and chronic mild antidepressant effects, respectively. The acute toxicity study revealed that macronutrients from eggs at 40% and 80% saturation displayed non-toxic effects (LD50 >5 g/kg), while those from beans, specifically at saturation of 80%, exhibited a relatively low level of toxicity (LD50 = 2.5 g/kg). Evaluation of antioxidant activity using the DPPH test yielded inconclusive results due to the influence of ethanol precipitation. In contrast, the H2O2 test demonstrated significant antioxidant potential in both macronutrients and micronutrients extracted from beans and eggs at all saturation levels. In investigating antidepressant properties, both macronutrients and micronutrients of bean and egg protein extracts at 40% and 80% saturation exhibited notable antidepressant effects, particularly the micronutrients at saturation of 80%. This antidepressant effect was characterized by a reduction in immobility time and an increase in sucrose preference.In conclusion, this study uncovers the multifaceted potential of protein extracts sourced from natural products, plant and animal origins, as agents for treating depression. It opens up new avenues for research, with implications ranging from neuroprotection to the management of depression, inspiring optimism for innovative approaches to mental health treatment.Read more

The mango, known as the {king of fruits}, is commercially significant in many parts of the world. In addition to offering a delicious tropical flavor, mangoes are a great source of nourishment and can make eating a satisfying and healthy sensory experience. Even though mango farming is known to exist in more than 120 nations, just 15 of them are responsible for more than 1% of the world’s supply. More than 60% of the mangoes produced worldwide are grown in India, China, Thailand, Indonesia and Mexico. The effects of climate change on agr...iculture must take into account the increasing CO2 concentration, a significant contributor to climate change, as CO2 is essential to critical plant functions, including photosynthesis. The fluctuation of temperature represents another climatic factor that affects mango productivity. The primary challenge facing the mango industry is irregular cultivation. The mango flowering was negatively impacted by the erratic distribution of cold nights and relatively warm winters. Mango output is already being impacted by rising average maximum temperatures. Therefore, regardless of mango growers, geniuses, or consumers, rapid climate change should be a top priority. A benefit of selection and breeding operations to adapt to climatic change is the high genetic variety of mangoes.Read more

For the first time, a method for calculating formulas of homologous series of chemical compounds of the systems (Aa+ – Bb+ – Cc–) and {Zn2+ – Ge4+ – P3–} in a generalized form is presented. The calculation is confirmed by the literature experimentally obtained compounds: thirteen compounds of the system (Na+ – Ti4+ – O2–), seven – systems (Li+ – Ti4+ – O2–), five – systems (K+ – V5a+ –  – O2–), eight – systems (Ba2+ – Cu2...+ – O2*). Homological series in (Aa+ – Bb+ – Cc–) have the following generalized form: A{t – k·r + nr – r)bcBracC{t – k·r + nr)ab and AtbcB{r – k·t + nt – t}acC (r – k·t + nt)ab.In (Zn2+ – Ge4+ – P3–) systems for the m-group the formulas of homologous series, that develops towards Ge3P4, have the following generalized form: Zn6tGe(6r – 6kt + 6n – 6t)P(8r – 8kt + 8n)  and for αm-homologous series – Zn6Ge3nP4(n + 1). A method for calculating formulas of homologous series of chemical compounds in a generalized form can be used for any system of chemical elements.Read more

People are suffering from” data obesity” as a result of the expansion and quick development of various Artificial Intelligence (AI) technologies and machine learning fields. The management of the current techniques is becoming more challenging due to the data created in the Smart-Health and Fintech service sectors. To provide stable and reliable methods for processing the data, several Machine Learning (ML) techniques were applied. Due to privacy-related issues with the aforementioned two providers, ML cannot fully use the data, whi...ch becomes difficult since it might not give the results that were expected. When the misuse and exploitation of personal data were gaining attention on a global scale and traditional machine learning (CML) was facing difficulties, Google introduced the concept of Federated Learning (FL). In order to enable the cooperative training of machine learning models among several organizations under privacy requirements, federated learning has been a popular research area. The expectation and potential of federated learning in terms of smart-health and fintech services are the main topics of this research.Read more

The currently existing Russian and other legislation, as well as special literature, do not contain a methodology for the formation of the business reputation of the organization’s personnel and as a result, there is no unambiguous perception of the business, professional qualities of personnel as an object of evaluation of the organization in the market system. Therefore, it is impossible to single out the share of the results of intellectual advantage in the goods and services produced. This confirms the requirements formulated in para...graph 4 of Accounting Regulation 14/2007 «Accounting for intangible assets», which states that the intellectual and business qualities of the organization’s personnel, their qualifications, and their ability to work are not included in the intangible assets (since they are inseparable from their carriers and cannot be used without them). Meanwhile, the interests of the leading economically developed countries of the world lie in the field of accelerated growth of knowledge acquisition and application of professional skills. This trend of development of economically developed countries forms the basis of competitiveness and efficiency of their work. It should be noted that in the world economy, there is insufficient theoretical elaboration and a special practical significance and relevance of the issue of assessing the business reputation of the personnel of an economic entity. The article presents a comprehensive methodology for evaluating the performance of industrial and production personnel (the standard-production methodology), which contributes to the formation of accounting and information support for the analysis of the activities of both structural divisions, responsibility centers, business segments and commercial organizations as a whole. The author’s standard-production methodology makes it possible to determine the business reputation of industrial and production personnel, which contradicts the official economic paradigm.Read more

Cinema, apart from its entertaining prospect, can flourish knowledge in various fields of daily life and, in particular, in the understanding of the natural world. It could be even embedded in the educational system, at all levels, so as to convey concepts that may be difficult for students in an enjoyable and understandable way. In this mini-review, the educational dimension of the cinema and the related television series is discussed, through the presentation of concepts and phenomena relevant to the natural sciences that have been approached... with characteristic scenes of popular cinema movies of our times. We present case studies from physics and astronomy, mathematics, materials science, and engineering that can be easily embedded in the educational curriculum. Notwithstanding the fact that watching movies cannot replace the traditional educational method, it can pose as an alternative, complementary tool for educators.Read more

The rapid development of wearable technology provides new opportunities for action data processing and classification techniques. Wearable sensors can monitor the physiological and motion signals of the human body in real-time, providing rich data sources for health monitoring, sports analysis, and human-computer interaction. This paper provides a comprehensive review of motion data processing and classification techniques based on wearable sensors, mainly including feature extraction techniques, classification techniques, and future developmen...t and challenges. First, this paper introduces the research background of wearable sensors, emphasizing their important applications in health monitoring, sports analysis, and human-computer interaction. Then, it elaborates on the work content of action data processing and classification techniques, including feature extraction, model construction, and activity recognition. In feature extraction techniques, this paper focuses on the content of shallow feature extraction and deep feature extraction; in classification techniques, it mainly studies traditional machine learning models and deep learning models. Finally, this paper points out the current challenges and prospects for future research directions. Through in-depth discussions of feature extraction techniques and classification techniques for sensor time series data in wearable technology, this paper helps promote the application and development of wearable technology in health monitoring, sports analysis, and human-computer interaction.Index Terms: Activity recognition, Wearable sensor, Feature extraction, ClassificationRead more

All professional technical assessment processes are fraught with uncertainty. If a decision is premised upon the result, the decision maker must understand the reliability of the performed assessment. A causal theory application is developed utilizing distinct (linguistic, ordered) terms and continuous (numerical) variables. It uncouples the methods from the result of the assessment obtained and focuses on those aspects that are important to the reliability assessment of the conclusion, not the answer itself. Matrices provide a means of charact...erizing the uncertainty of the methods and information available for each principal issue impacting the reliability. These matrices are determined as paired qualitative assessments of the Quality of the Measures Used and the Quality of Implementation of component description measures. Each is qualified by two to five grades, allowing three, five, seven, or nine quality distinctions for the assessed element. Uncertainty β values are determined for each component of the assessment combined by either an RMS procedure or a weighted average and converting a numerical value back to a consistent linguistic term. This procedure yields a basis for using good judgment while being sensible and reasonably cautious by independently determining the reliability using a carefully considered approach. California State University has assessed seismic retrofit priorities for 56 buildings using this method and has committed to its continuing use as its retrofit priority evaluation tool.Read more

A new design of a fine positioner or high precision driven unit with a large positioning range is proposed for a custom-made in-situ indenter device equipped inside an SEM chamber. The design configuration of the proposed system is size-effective for the confined working area of the SEM chamber. The indentation depths can be precisely varied by controlling the fine positioner driven by a piezoelectric actuator. The main goal is to achieve very deep penetrations toward the bottom layers of tall or large-size scale specimens by single indentation..., without the need for sequential indentations. Thus, the proposed design can eliminate the need for sequential adjustments of the specimen position with respect to the indenter tip as currently being practiced by the researchers. The specimen position adjustment after each indentation heavily depends on the coarse positioner and its accuracy level in a sub-millimeter regime which could result in position errors and unwanted lateral forces in the nanoindentation process. Therefore, the sequential indentations technique could lead to considerable variations in the outcomes of nanoindentation tests done on similar specimens. The proposed design will be realized to deploy in the Continuous Stiffness Measurement (CSM) techniques generally used to evaluate elastic properties as a function of continuous penetration depth with high-frequency loading and unloading cycles.Read more

The article obtained systematized, scientifically substantiated gross, technical, economic, and environmental energy resource potentials from the introduction and use of solar energy technologies. The technical, economic, and environmental priorities of power plants were assessed in terms of energy efficiency, fuel economy, and the environmental impact per square meter from conversion to thermal and electrical energy in the city of Arkadag.The calculated results are, kWh/m2 per year: gross resource potential of solar energy - 1844.6; the techni...cal potential for conversion into thermal and electrical energy is equal to - 1256.44 and 242.44; economic - 502.6 and 96.98 kg fuel equivalent/m2 per year; environmental reduction in emissions of various harmful substances into the environment when using solar photovoltaic modules in the city of Arkadag will be: with annual electricity generation per m2 - 242.44 kW⋅h, annual fuel consumption savings - 96.96 kg. e., the reduction in emissions will be, kg per year: SO2 – 2.0; NOx – 1.1; CO – 0.14; CH4 – 0.29; CO2 – 155.0; solids – 0.21; when converted into thermal energy per m2 and annual production of 1256.4 kW⋅h, annual fuel savings are 502.6 kg of fuel equivalent; emission reduction will be, kg per year: SO2 – 10.4; NOx – 5.6; CO – 0.73; CH4 – 1.53; CO2 – 803.5; solids – 1.1.Empirical equations (1-5) have been obtained taking into account the gross, technical, economic, and environmental resource potentials of solar energy in the city of Arkadag, it is possible to carry out energy and environmental forecasting when drawing up a feasibility study.Read more

The article examines the priorities and prospects of the road map for the development of renewable energy using the example of Turkmenistan. The main scientific conditions of the goal, objectives, principles of public policy, a heterogeneous class of renewable technologies, the main scientific conditions of the road map for sustainable development, the environmental aspect of climate change, mitigation potential, and costs are presented. The compiled roadmap for the use of renewable energy sources outlines the expected energy, economic, and env...ironmental effects from the use of renewable energy technologies in remote areas from the centralized power line. The author believes that the outlined development roadmap for the use of renewable energy sources will become the basis for drawing up programs in other countries, depending on natural, climatic, and geographical conditions. Thus, the road map for the development of renewable energy sources, the use of local renewable energy resources, can reduce the need for fossil fuels in some cases by up to 80% and will significantly reduce the anthropogenic load on the environment. The introduction of renewable energy sources is one of the most relevant and promising for the development of the desert and the fight against desertification in the Karakum.Read more

Economists often provide predictions about future interest or policy rates. In contrast to stock market predictions, these forecasts are typically regarded seriously and presented with a degree of accuracy. This paper explores whether placing more confidence in policy rate predictions than stock market predictions is reasonable. It begins by examining historical policy rates predictions in Sweden, comparing them to actual rates to assess their accuracy. The paper then delves into the discussion of how costs of mispredictions, such as sudden and... unexpected policy rate increases, can and should be addressed. Despite the Central Bank making predictions within confidence intervals and the banking sector regulating individuals’ borrowing, the burden of unpredicted rate increases falls almost entirely on individuals. The paper addresses whether that is reasonable.Read more