Ethnomedicine at IgMin Research | Biology Group

Six alkaloid compounds were isolated (the discovery of a natural drug, which is a combination of the six alkaloid compounds). Alkaloids viz., 1,3,5-Triazine-2-carboxylic acid, 4-amino-6-methyl; 1,2,4-Triazino[5,6-E][1,2,4]-triazine-3,6-dione, hexahydro; 2-(4,5-Dihydro-3-methyl-5-oxo-1-phenyl-4-pyrazole)-5-nitrobenzoic acid; 4-metyl-3,4-dihydro-[1,2,3] trizolo [4,5-d] pyrimidine-5,7-dione; Propanoic acid-3-(perhydro-2,5-dioxo-imidazol [4,5-d] imidazole-1-yl) and 1,2,3-Triazolo[4,5-f] benzotriazole- 4,8(4H,8H)-dione, were isolated from Cinnamomum... verum cortexes by using ethanolic acetic acid, sulphuric acid, and ammonia solvents, and they were characterized by using preliminary qualitative tests, gas chromatography-mass spectrumGC-MASS.The medicinal efficacy was studied for these six alkaloidic compounds theoretically by using the Autodock program and the results showed the presence of high efficacy of the compounds. Then the medicinal efficacy was measured biologically for the six compounds mixture in vitro depending on the synergistic interaction principle by using various concentrations (5, 10, 15, 20, and 25 mg/ml) by using of agar diffusion technique. The results showed that the six alkaloidic compounds’ mixture is biologically active against Alternaria alternate fungus, where the inhibition zone diameters were recorded equal to 27, 33, 41, 45, and 49 mm respectively towards the pathogenic fungus. Also, cytotoxicity tests for the different concentrations of six active alkaloid compounds mixture proved there is no toxic effect belonging to them towards red blood cells, and no hemolysis effect appeared in blood cells. Therefore, six alkaloid compounds isolated from Cinnamomum verum cortexes can be used as active drugs for the treatment of various diseases especially those caused by pathogenic fungi represented by Alternaria alternate, without any side effects.Read more

The article provides information about modern problems of writing the Kazakh language, the importance of its role and development in the context of mass digitization using artificial intelligence technologies and computational linguistics methods. The incorrectness of the current alphabet of the Kazakh language based on the Cyrillic alphabet is proved in connection with the inclusion of Cyrillic letters in it, denoting phonemes that are not included in its sound structure. The necessity of reforming the Kazakh writing by replacing the incorrect... alphabet is substantiated. Errors and contradictions are shown in the approved version of the Kazakh alphabet based on the Latin alphabet, as well as the alphabet proposed as a replacement for the approved one, in which some previous errors are repeated. In both cases, no analysis and clarification of the sound system of the Kazakh language, which is the basis of any alphabet, is carried out. In this study, to clarify the sound system of the Kazakh language, experiments were carried out to determine the articulation and acoustic features of Kazakh sounds with the help the computer programs used for many natural languages. In the articulation analysis, special attention was paid to vowels, which give rise to various contradictions in the Kazakh letter. It is proposed to use a new classification of vowels according to four binary features, rather than the traditional classification according to three binary features. Acoustic analysis uses the method of formant analysis, which is aimed at identifying certain formants in the spectrogram. The formant is obtained using a spectrograph. Quantitatively, the formants correspond to the maxima in the speech spectrum and usually appear on spectrograms as horizontal bands. After determining the composition and classification of the sound system of the Kazakh language, two variants of the alphabet based on the Latin alphabet are proposed: the first one is based on the Turkish alphabet using diacritical marks; the second is based on the English alphabet using digraphs. The second option offers ways to solve problems that arise when using digraphs. In conclusion, information is provided on the ongoing and ongoing work in Kazakhstan related to the creation of smart systems in the Kazakh language based on the methods and technologies of artificial intelligence and computational linguistics, the results of which are reflected in the list of sources.Read more

Since time immemorial, Indigenous communities have always perceived the landscape as a complex web of living, physical, and spiritual things. These communities have always relied on their Indigenous knowledge systems (IKS), emphasizing ancestral burial grounds, mountains, caves, rivers, pools, forests, monuments, and other cultural diacritics as symbols of place identity. In addition, myriad metaphors like taboos, legends, tales, folklore, myths, proverbs, stories, and practices, also constituted an integral part of Indigenous cultural and natu...re connections. This heritage was constantly imagined and configured to cement human-nature relations. However, the advent of colonialism severely violated this status quo, thereby causing deep environmental, political, and social crises. Through imposing a hegemonic scientific paradigm, knowledge compartmentalization, and capitalist aggrandizing practices, the original harmonious human-nature praxis premised on IKS was disrupted. To this day, the exclusionary colonial legacy and poisoned ‘sense of place’ remains our greatest threat to climate and environmental stability. Thus, this paper advocates for the recentralization of IKS as a valid way of knowing with already inbuilt human and natural disaster management solutions. By pivoting Rozvi narratives premised on five mountains, namely; Manyanga in Bubi district, Mavangwe, MunwewaMwari and Bepe in Buhera district, and Mutikwiri in Maungwe near Rusape town, all situated in former Butua/Guruuswa regions of Zimbabwe as case studies, the power of ancient wisdom as a holistic epistemic approach towards sustainable human-nature relations is explicated.Read more