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Biology Group Research Article 記事ID: igmin281

Synergistic Assessment of Supplementation of Ascorbic Acid and Massularia acuminata Extracts on Serum Electrolyte and Lipid Profile Indices of Dyslipidemia in Adult Wistar Rats Exposed to Aluminum Chloride Toxicity

Biochemistry DOI10.61927/igmin281 Affiliation

Affiliation

    Department of Biochemistry, Faculty of Science, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria

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要約

Background: Aluminum chloride (AlCl3) toxicity is a growing concern due to its prevalence usage in various industrial and environmental settings. Prolonged exposure to aluminum chloride can lead to oxidative stress, electrolyte imbalances, and alterations in lipid metabolism. This study aimed to investigate the effects of supplementation of ascorbic acid and Massularia acuminata extracts on electrolyte function and lipid profile parameters in adult Wistar rats exposed to aluminum chloride toxicity. 
Methodology: The stem barks of Massularia acuminata were air-dried at room temperature for thirty (30) days and were mechanically ground into fine powder by using an electrical mill. The powder was kept in air-tight container until use. Six hundred (600 g) of the dried powders was dissolved in 4 litres of 80 % (v/v) of methanol, ethanol and butanol respectively for 72 h with occasional agitation using sterile rod. The resulting mixture obtained was then filtered using pieces of white cotton gauze and concentrated in a rotary evaporator following by dryness under vacuo at 40 0C in a rotary evaporator. The extracts that were obtained were then concentrated to dryness ‘in vacuo’ to yield the respective solvent extracts For the animal study, then, fifty Adult Wistar rats was randomly divided into several groups, including a control group, an aluminum chloride-exposed group, and treatment groups supplemented with ascorbic acid, Massularia acuminata extracts, and combination of both in varied doses. The dosage of supplementation was determined based on preliminary experiments and relevant literature. The rats in the aluminum chloride-exposed group and the treatment groups received oral administration of aluminum chloride at a specific dose of (34 mg/kg) for a defined duration to induce toxicity. The control group received a placebo. The treatment groups received supplementation of Ascorbic Acid and Massularia acuminata extracts received daily oral supplementation of ascorbic acid, Massularia acuminata extracts, or a combination of both, while the control and aluminum chloride-exposed groups received a placebo. 
Results: The result showed that there was a significant (p < 0.05) decrease in the lipid profile of Total Cholesterol (TC), Very Low-Density Lipoprotein (VLDL) and a non-significant decrease in High Density Lipoprotein (HDL) treated with vitamin C while a significant decrease in the level of HDL, VLDL, LDL and cholesterol were observed from the groups treated with the various plant extracts. 
Conclusion: From the study, it can therefore be concluded that ethanol leaf extract of Massularia acuminata has protective effect against aluminium chloride induced hepatotoxicity, oxidative stress and alterations in lipid and electrolyte profile in Wistar rats. 

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参考文献

    1. De Backer G, Jankowski P, Kotseva K, Mirrakhimov E, Reiner Ž, Rydén L, Tokgözoğlu L, Wood D, De Bacquer D; EUROASPIRE V collaborators; Writing Committee; Scientific Steering/ Executive Committee; Coordinating centre; Diabetes centre; Data management centre; Statistical analysis centre; Central laboratory; Study centres, organisations, investigators and other research personnel (National Co-ordinators in each country are indicated by asterisk. Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries. Atherosclerosis. 2019 Jun;285:135-146. doi: 10.1016/j.atherosclerosis.2019.03.014. Epub 2019 Apr 24. PMID: 31054483.
    2. Vollset SE, Goren E, Yuan CW, Cao J, Smith AE, Hsiao T, Bisignano C, Azhar GS, Castro E, Chalek J, Dolgert AJ, Frank T, Fukutaki K, Hay SI, Lozano R, Mokdad AH, Nandakumar V, Pierce M, Pletcher M, Robalik T, Steuben KM, Wunrow HY, Zlavog BS, Murray CJL. Fertility, mortality, migration, and population scenarios for 195 countries and territories from 2017 to 2100: a forecasting analysis for the Global Burden of Disease Study. Lancet. 2020 Oct 17;396(10258):1285-1306. doi: 10.1016/S0140-6736(20)30677-2. Epub 2020 Jul 14. PMID: 32679112; PMCID: PMC7561721.
    3. Swan SH, Elkin EP, Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect. 2000 Oct;108(10):961-6. doi: 10.1289/ehp.00108961. PMID: 11049816; PMCID: PMC1240129.
    4. Mieusset R, Bujan L. Testicular heating and its possible contributions to male infertility: a review. Int J Androl. 1995 Aug;18(4):169-84. doi: 10.1111/j.1365-2605.1995.tb00408.x. PMID: 7591190.
    5. Swami CG, Ramanathan J, Charan Jeganath C. Noise exposure effect on testicular histology, morphology and on male steroidogenic hormone. Malays J Med Sci. 2007 Jul;14(2):28-35. PMID: 23515367; PMCID: PMC3595009.
    6. Rahmati-Ahmadabad S, Broom DR, Ghanbari-Niaki A, Shirvani H. Effects of exercise on reverse cholesterol transport: A systemized narrative review of animal studies. Life Sci. 2019 May 1;224:139-148. doi: 10.1016/j.lfs.2019.03.058. Epub 2019 Mar 25. PMID: 30922848.
    7. Ding X, Zhang W, Li S, Yang H. The role of cholesterol metabolism in cancer. Am J Cancer Res. 2019 Feb 1;9(2):219-227. PMID: 30906624; PMCID: PMC6405981.
    8. Vazquez JM, Roldan ER. Diacylglycerol species as messengers and substrates for phosphatidylcholine re-synthesis during Ca2+-dependent exocytosis in boar spermatozoa. Mol Reprod Dev. 1997 Sep;48(1):95-105. doi: 10.1002/(SICI)1098-2795(199709)48:1<95::AID-MRD12>3.0.CO;2-V. PMID: 9266766.
    9. Ickowicz D, Finkelstein M, Breitbart H. Mechanism of sperm capacitation and the acrosome reaction: role of protein kinases. Asian J Androl. 2012 Nov;14(6):816-21. doi: 10.1038/aja.2012.81. Epub 2012 Sep 24. PMID: 23001443; PMCID: PMC3720105.
    10. Cohen-Dayag A, Tur-Kaspa I, Dor J, Mashiach S, Eisenbach M. Sperm capacitation in humans is transient and correlates with chemotactic responsiveness to follicular factors. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11039-43. doi: 10.1073/pnas.92.24.11039. PMID: 7479932; PMCID: PMC40566.
    11. Kim E, Baba D, Kimura M, Yamashita M, Kashiwabara S, Baba T. Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18028-33. doi: 10.1073/pnas.0506825102. Epub 2005 Dec 5. PMID: 16330764; PMCID: PMC1312394.
    12. Villaverde AISB, Netherton J, Baker MA. From Past to Present: The Link Between Reactive Oxygen Species in Sperm and Male Infertility. Antioxidants (Basel). 2019 Dec 3;8(12):616. doi: 10.3390/antiox8120616. PMID: 31817049; PMCID: PMC6943565.
    13. Thundathil J, Gil J, Januskauskas A, Larsson B, Soderquist L, Mapletoft R, Rodriguez-Martinez H. Relationship between the proportion of capacitated spermatozoa present in frozen-thawed bull semen and fertility with artificial insemination. Int J Androl. 1999 Dec;22(6):366-73. doi: 10.1046/j.1365-2605.1999.00194.x. PMID: 10624605.
    14. Huang J, Feigenson GW. A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers. Biophys J. 1999 Apr;76(4):2142-57. doi: 10.1016/S0006-3495(99)77369-8. PMID: 10096908; PMCID: PMC1300186.
    15. Pandit SA, Jakobsson E, Scott HL. Simulation of the early stages of nano-domain formation in mixed bilayers of sphingomyelin, cholesterol, and dioleylphosphatidylcholine. Biophys J. 2004 Nov;87(5):3312-22. doi: 10.1529/biophysj.104.046078. Epub 2004 Aug 31. PMID: 15339797; PMCID: PMC1304799.
    16. Leung GP, Cheung KH, Leung CT, Tsang MW, Wong PY. Regulation of epididymal principal cell functions by basal cells: role of transient receptor potential (Trp) proteins and cyclooxygenase-1 (COX-1). Mol Cell Endocrinol. 2004 Mar 15;216(1-2):5-13. doi: 10.1016/j.mce.2003.10.077. PMID: 15109739.
    17. Cohen DJ, Maldera JA, Vasen G, Ernesto JI, Muñoz MW, Battistone MA, Cuasnicú PS. Epididymal protein CRISP1 plays different roles during the fertilization process. J Androl. 2011 Nov-Dec;32(6):672-8. doi: 10.2164/jandrol.110.012922. Epub 2011 Mar 25. PMID: 21441424.
    18. Maldera JA, Weigel Muñoz M, Chirinos M, Busso D, G E Raffo F, Battistone MA, Blaquier JA, Larrea F, Cuasnicu PS. Human fertilization: epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3. Mol Hum Reprod. 2014 Apr;20(4):341-9. doi: 10.1093/molehr/gat092. Epub 2013 Dec 12. PMID: 24334245.
    19. Lin Y, Kan FW. Regionalization and redistribution of membrane phospholipids and cholesterol in mouse spermatozoa during in vitro capacitation. Biol Reprod. 1996 Nov;55(5):1133-46. doi: 10.1095/biolreprod55.5.1133. PMID: 8902227.
    20. Simons K, Ehehalt R. Cholesterol, lipid rafts, and disease. J Clin Invest. 2002 Sep;110(5):597-603. doi: 10.1172/JCI16390. PMID: 12208858; PMCID: PMC151114.
    21. Yakubu MT, Akanji MA, Oladiji AT. Male sexual dysfunction and methods used in assessing medicinal plants with aphrodisiac potentials: A review. Pharmacognosy Rev. 2008;1(1):45–55.
    22. Yakubu MT, Awotunde OS, Ajiboye TO, Oladiji AT, Akanji MA. Pro-sexual effects of aqueous extracts of Massularia acuminata root in male Wistar rats. Andrologia. 2011 Oct;43(5):334-40. doi: 10.1111/j.1439-0272.2011.01080.x. PMID: 21951198.
    23. Wang M, Ruan DY, Chen JT, Xu YZ. Lack of effects of vitamin E on aluminium-induced deficit of synaptic plasticity in rat dentate gyrus in vivo. Food Chem Toxicol. 2002 Apr;40(4):471-8. doi: 10.1016/s0278-6915(01)00094-1. PMID: 11893406.
    24. Priest ND. The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: review and study update. J Environ Monit. 2004 May;6(5):375-403. doi: 10.1039/b314329p. Epub 2004 Apr 23. PMID: 15152306.
    25. Kutlubay R, Oguz EO, Abban G, Turgut S. Amelioration of aluminium-induced liver damage by vitamin E. Saudi Med J. 2007 Feb;28(2):197-200. PMID: 17268696.
    26. Majeda AAJ. Propolis cardioprotective role from the impact of aluminum chloride in female rabbits. Basic J Vet Res. 2015;14:136–149.
    27. Goma AA, Tohamy HG. Impact of some heavy metals toxicity on behaviour, biochemical and histopathological alterations in adult rats. Adv Anim Vet Sci. 2016;4(9):494–500.
    28. Eman EE, Doha YA, Naveen AE. Influence of chelating therapy against aluminum chloride-induced immune suppression and hematological disorders in rabbits. Comp Clin Pathol. 2013;22:63–73.
    29. Ahmed MK, Anuka JA, Tanko Y. Department of human physiology, Faculty of Medicine. 2011.
    30. Kawahara M, Tanaka K, Kato-Negishi M. Neurotoxicity of aluminum and its link to neurodegenerative diseases. Metallomics Research. rev-47 -res-67. 2021.
    31. Kawahara M, Kato-Negishi M. Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses. Int J Alzheimers Dis. 2011 Mar 8;2011:276393. doi: 10.4061/2011/276393. PMID: 21423554; PMCID: PMC3056430.
    32. El-Sayed WM, Al-Kahtani MA, Abdel-Moneim AM. Prophylactic and therapeutic effects of taurine against aluminum-induced acute hepatotoxicity in mice. J Hazard Mater. 2011 Aug 30;192(2):880-6. doi: 10.1016/j.jhazmat.2011.05.100. Epub 2011 Jun 6. PMID: 21703760.
    33. Ochmański W, Barabasz W. Glin--wystepowanie i toksyczność dla organizmów [Aluminum--occurrence and toxicity for organisms]. Przegl Lek. 2000;57(11):665-8. Polish. PMID: 11293216.
    34. Guo CH, Liao SY, Yuan CY, Hsu GS. Effects of peritoneal aluminum overload on polyamines and nitric oxide contents of testes and epididymis in the mice. Environ Toxicol Pharmacol. 2006 Jan;21(1):1-7. doi: 10.1016/j.etap.2005.03.010. Epub 2005 Jun 13. PMID: 21783633.
    35. Guo CH, Lu YF, Hsu GS. The influence of aluminum exposure on male reproduction and offspring in mice. Environ Toxicol Pharmacol. 2005 Jul;20(1):135-41. doi: 10.1016/j.etap.2004.11.007. Epub 2005 Jan 13. PMID: 21783580.
    36. Yousef MI, Kamel KI, El-Guendi MI, El-Demerdash FM. An in vitro study on reproductive toxicity of aluminium chloride on rabbit sperm: the protective role of some antioxidants. Toxicology. 2007 Oct 8;239(3):213-23. doi: 10.1016/j.tox.2007.07.011. Epub 2007 Jul 17. PMID: 17714845.
    37. Allagui MS, Feriani A, Saoudi M, Badraoui R, Bouoni Z, Nciri R, Murat JC, Elfeki A. Effects of melatonin on aluminium-induced neurobehavioral and neurochemical changes in aging rats. Food Chem Toxicol. 2014 Aug;70:84-93. doi: 10.1016/j.fct.2014.03.043. Epub 2014 Apr 12. PMID: 24727051.
    38. Zhang L, Jin C, Lu X, Yang J, Wu S, Liu Q, Chen R, Bai C, Zhang D, Zheng L, Du Y, Cai Y. Aluminium chloride impairs long-term memory and downregulates cAMP-PKA-CREB signalling in rats. Toxicology. 2014 Sep 2;323:95-108. doi: 10.1016/j.tox.2014.06.011. Epub 2014 Jun 25. PMID: 24973631.
    39. Xie CX, Yokel RA. Aluminum facilitation of iron-mediated lipid peroxidation is dependent on substrate, pH and aluminum and iron concentrations. Arch Biochem Biophys. 1996 Mar 15;327(2):222-6. doi: 10.1006/abbi.1996.0113. PMID: 8619606.
    40. Ozben T. Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci. 2007 Sep;96(9):2181-96. doi: 10.1002/jps.20874. PMID: 17593552.
    41. Kutlubay R, Oğuz EO, Can B, Güven MC, Sinik Z, Tuncay OL. Vitamin E protection from testicular damage caused by intraperitoneal aluminium. Int J Toxicol. 2007 Jul-Aug;26(4):297-306. doi: 10.1080/10915810701470952. PMID: 17661220.
    42. Al-Kahtani MA. Renal damage mediated by oxidative stress in mice treated with aluminum chloride: Protective effects of taurine. Journal of Biological Sciences. 2010;10:584-595.
    43. Guo CH, Lin CY, Yeh MS, Hsu GS. Aluminum-induced suppression of testosterone through nitric oxide production in male mice. Environ Toxicol Pharmacol. 2005 Jan;19(1):33-40. doi: 10.1016/j.etap.2004.02.009. PMID: 21783460.
    44. Chinoy NJ, Sorathia HP, Jhala DD. Fluoride+aluminium induced toxicity in mice testis with giant cells and its reversal by vitamin C. Fluoride. 2005;38:109-114.
    45. Chinoy N, Momin R, Sorathia H, Jhala D. Recovery from fluoride + aluminium toxicity in vas deferens, seminal vesicle, and ventral prostate of mice by vitamin C. Fluoride. 2005;38(2):122-6.
    46. Asard H, May J, Smirnoff N. Vitamin C: its functions and biochemistry in animals and plants. Garland Science; 2003.
    47. Jelodar G, Akbari A, Nazifi S. The prophylactic effect of vitamin C on oxidative stress indexes in rat eyes following exposure to radiofrequency wave generated by a BTS antenna model. Int J Radiat Biol. 2013 Feb;89(2):128-31. doi: 10.3109/09553002.2012.721051. Epub 2012 Sep 7. PMID: 22892052.
    48. Luck MR, Jeyaseelan I, Scholes RA. Ascorbic acid and fertility. Biol Reprod. 1995 Feb;52(2):262-6. doi: 10.1095/biolreprod52.2.262. PMID: 7711198.
    49. Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999 Jun;69(6):1086-107. doi: 10.1093/ajcn/69.6.1086. PMID: 10357726.
    50. Carr A, Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J. 1999 Jun;13(9):1007-24. doi: 10.1096/fasebj.13.9.1007. PMID: 10336883.
    51. Vucic M, Petrovic S, Mesic R, Rocic B. An automated immunoturbidimetric assay for HbA1c determination. Clin Chem Lab Med. 1999;37(Suppl):S199.
    52. Barham D, Trinder P. An improved colour reagent for the determination of blood glucose by the oxidase system. Analyst. 1972 Feb;97(151):142-5. doi: 10.1039/an9729700142. PMID: 5037807.
    53. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470-5. PMID: 4818200.
    54. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470-5. PMID: 4818200.
    55. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973 May;19(5):476-82. PMID: 4703655.
    56. Demacker PN, Hijmans AG, Vos-Janssen HE, van't Laar A, Jansen AP. A study of the use of polyethylene glycol in estimating cholesterol in high-density lipoprotein. Clin Chem. 1980 Dec;26(13):1775-9. PMID: 7438421.
    57. Bakare O, Adedugbe O, Owoloye A. Aluminum chloride-induced oxidative damage to serum and combined intervention of ascorbic acid and Massularia acuminata on selected markers of in vivo antioxidant enzymes in Wistar rats. J Chem Nutr Biochem. 2021;2(1):13-28.
    58. Abdel-Wahab WM. Aluminium chloride-induced toxicity and oxidative stress in liver of male rats: protection by melatonin. Life Sci J. 2012;9(4):1173-81.
    59. Shrivastava S. Amelioration of aluminium-induced toxicity by Allium sativum. Sci Res Essays. 2013;8(4):168-77.
    60. Chatterjea MN, Shinde R. Textbook of Medical Biochemistry. 5th ed. AYPE; 2002;154-7.
    61. Hillstrom RJ, Yacapin-Ammons AK, Lynch SM. Vitamin C inhibits lipid oxidation in human HDL. J Nutr. 2003 Oct;133(10):3047-51. doi: 10.1093/jn/133.10.3047. PMID: 14519782.
    62. Mayes PA. Cholesterol synthesis, transport, and excretion. In: Harper’s Biochemistry. 24th ed. California: Prentice-Hall International Inc. 1996;271-80.
    63. White A, Handler P, Smith EL, Hill RL, Cehman R. Principles of Biochemistry. Tokyo: McGraw-Hill Kogakusha Ltd. 1978;1223:1360.
    64. White A, Handler P, Smith EL, Hill RL, Cehman R. Principles of Biochemistry. Tokyo: McGraw-Hill Kogakusha Ltd. 1978;1223:1360.
    65. Anderson JW, Gowri MS, Turner J, Nichols L, Diwadkar VA, Chow CK, Oeltgen PR. Antioxidant supplementation effects on low-density lipoprotein oxidation for individuals with type 2 diabetes mellitus. J Am Coll Nutr. 1999 Oct;18(5):451-61. doi: 10.1080/07315724.1999.10718883. PMID: 10511327.
    66. Bsoul SA, Terezhalmy GT. Vitamin C in health and disease. J Contemp Dent Pract. 2004 May 15;5(2):1-13. PMID: 15150630.
    67. Guyton AC, Hall JE. Textbook of Medical Physiology (13th ed.). Elsevier. 2006.
    68. Guo CH, Lu YF, Hsu GS. The influence of aluminum exposure on male reproduction and offspring in mice. Environ Toxicol Pharmacol. 2005 Jul;20(1):135-41. doi: 10.1016/j.etap.2004.11.007. Epub 2005 Jan 13. PMID: 21783580.
    69. Habashi JP, Doyle JJ, Holm TM, Aziz H, Schoenhoff F, Bedja D, Chen Y, Modiri AN, Judge DP, Dietz HC. Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science. 2011 Apr 15;332(6027):361-5. doi: 10.1126/science.1192152. PMID: 21493863; PMCID: PMC3097422.
    70. Jackson G, Gillies H, Osterloh I. Past, present, and future: a 7-year update of Viagra (sildenafil citrate). Int J Clin Pract. 2005 Jun;59(6):680-91. doi: 10.1111/j.1368-5031.2005.00578.x. PMID: 15924597.
    71. Whitescarver SA, Ott CE, Jackson BA, Guthrie GP Jr, Kotchen TA. Salt-sensitive hypertension: contribution of chloride. Science. 1984 Mar 30;223(4643):1430-2. doi: 10.1126/science.6322303. PMID: 6322303.
    72. Hall JE, Brands MW, Henegar JR. Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney. J Am Soc Nephrol. 1999 Apr;10 Suppl 12:S258-65. PMID: 10201880.
    73. Hall N, Karras M, Raine JD, Carlton JM, Kooij TW, Berriman M, Florens L, Janssen CS, Pain A, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell SL, Rajandream MA, Carucci DJ, Yates JR 3rd, Kafatos FC, Janse CJ, Barrell B, Turner CM, Waters AP, Sinden RE. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science. 2005 Jan 7;307(5706):82-6. doi: 10.1126/science.1103717. PMID: 15637271.
    74. Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg. 2005 Jul;31(7 Pt 2):814-7; discussion 818. doi: 10.1111/j.1524-4725.2005.31725. PMID: 16029672.
    75. Wang Y, Ma H, Hao X, Yang J, Chen Q, Lu L, Zhang R. Low serum calcium is associated with left ventricular systolic dysfunction in a Chinese population with coronary artery disease. Sci Rep. 2016 Feb 29;6:22283. doi: 10.1038/srep22283. PMID: 26924008; PMCID: PMC4770278.
    76. Li S, Na L, Li Y, Gong L, Yuan F, Niu Y, Zhao Y, Sun C. Long-term calcium supplementation may have adverse effects on serum cholesterol and carotid intima-media thickness in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2013 Nov;98(5):1353-9. doi: 10.3945/ajcn.113.062844. Epub 2013 Sep 18. Erratum in: Am J Clin Nutr. 2014 May;99(5):1143. PMID: 24047919.
    77. Bogdanović M, Janeva AB, Bulat P. Histopathological changes in rat liver after a single high dose of aluminium. Arh Hig Rada Toksikol. 2008 Jun;59(2):97-101. doi: 10.2478/10004-1254-59-2008-1859. PMID: 18573746.
    78. Boskou D. Sources of natural phenolic antioxidants. Trend in Food Science Technology. 2006;17: 505-512.
    79. Frei B, Traber MG. The new role of vitamin C in oxidative stress. Nutrition Reviews. 2001;59(8):309-317.
    80. Lu X, Wang Y, Meng H, Chen P, Huang Y, Wang Z, Zhou N, Li C, Wang L, Jia E, Yang Z. Association of admission serum calcium levels and in-hospital mortality in patients with acute ST-elevated myocardial infarction: an eight-year, single-center study in China. PLoS One. 2014 Jun 13;9(6):e99895. doi: 10.1371/journal.pone.0099895. PMID: 24926660; PMCID: PMC4057419.
    81. Maqdasy S, Baptissart M, Vega A, Baron S, Lobaccaro JM, Volle DH. Cholesterol and male fertility: what about orphans and adopted? Mol Cell Endocrinol. 2013 Apr 10;368(1-2):30-46. doi: 10.1016/j.mce.2012.06.011. Epub 2012 Jul 3. PMID: 22766106.
    82. Wang HZ, Lee SW, Christ GJ. Comparative studies of the maxi-K (K(Ca)) channel in freshly isolated myocytes of human and rat corpora. Int J Impot Res. 2000 Feb;12(1):9-18. doi: 10.1038/sj.ijir.3900444. PMID: 10982307.
    83. Xu X, Bittman R, Duportail G, Heissler D, Vilcheze C, London E. Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide. J Biol Chem. 2001 Sep 7;276(36):33540-6. doi: 10.1074/jbc.M104776200. Epub 2001 Jun 29. PMID: 11432870.

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