The Model for Clinical, Laboratory, and Genetic Prediction of Recurrent Ischemic Stroke against the Background of Laboratory Aspirin Resistance using Machine Learning

Anastasia V Anisimova; Sergey S Galkin; Anastasia S Gunchenko; Tatyana V Nasedkina; Igor V Vorobiev

doi:10.61927/igmin143

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Biology Group Mini Review 記事ID: igmin143

The Model for Clinical, Laboratory, and Genetic Prediction of Recurrent Ischemic Stroke against the Background of Laboratory Aspirin Resistance using Machine Learning

Molecular Biology Genomics Biochemistry DOI10.61927/igmin143

Anastasia V Anisimova ¹ ,

Sergey S Galkin ^* ¹ ,

Anastasia S Gunchenko ¹ ,

Tatyana V Nasedkina ² and

Igor V Vorobiev ²

Affiliation

¹Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

²Engelhardt Institute of Molecular Biology RAS, Moscow, Russia

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要約

The aim of the study was to determine the incidence of laboratory aspirin resistance; and to study the associations of genetic markers and clinical and laboratory parameters (including parameters of the platelet hemostasis) in patients with non-cardioembolic ischemic stroke using machine learning methods to assess the prognosis of recurrent ischemic strokes. Clinical and laboratory data (including induced platelet aggregation) were analyzed from 296 patients with ischemic stroke who were treated in the stroke center of City Clinical Hospital No. 1 named after. N.I. Pirogov. The frequencies of polymorphic variants of the ITGB3, GPIba, TBXA2R, ITGA2, PLA2G7, HMOX1, PTGS1, PTGS2, ADRA2A, ABCB1, PEAR1 genes and intergenic region 9p21.3) in patients with non-cardioembolic ischemic stroke, which were identified using hydrogel biochip technology, were determined. Using the developed machine learning model, additional clinical and genetic factors influencing the development of laboratory aspirin resistance and recurrent ischemic stroke were studied. In the future, the identified factors can be used for differentiated prevention of recurrent ischemic strokes.

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