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Abstract

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Science Group Research Article Article ID: igmin113

Benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidines: Past and Present

Organic Chemistry Computational ChemistryBiochemistry
AA Harutyunyan *
Affiliation

Affiliation

    The Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NAS RA 26, Azatutyan Ave., Yerevan, 0014, Armenia

DOI10.61927/igmin113 Fulltext HTML Fulltext PDF Cite this article
DOI10.61927/igmin113 Fulltext HTML Fulltext PDF Cite this article

Abstract

Synthetic approaches to the construction of the heterocyclic benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidine system based on heterocyclizations of substituted benzimidazoles and a new alternative strategy based on 2,4,6-trisubstituted pyrimidinyl-5-propanoic acids are considered. The latter method has been shown to be a successful addition to previously described methods, since it allows one to bypass the significant limitations associated with the use of substituted benzimidazoles and allows the introduction of functional substituents at different positions of the heterocycle that are inaccessible by other methods. The available information on derivatives of this heterocyclic system and their biological properties is summarized.

Figures

Structures of symmetrically nonequivalent molecules of compound 12b with ordered structure (a) and with disordered structure (b). Ellipsoids are depicted with 50% probability. Figure 1: Structures of symmetrically nonequivalent molecule...
Tetramer of molecules of compound 12b formed using non-classical hydrogen bonds. Figure 2: Tetramer of molecules of compound 12b formed using...
General view of the 6-benzyl-4-methyl-2-phenilbenzo[4’,5’]imidazo [2’,1’:6,1]pyrido[2,3-d]pyrimidyn (14a). Figure 3: General view of the 6-benzyl-4-methyl-2-phenilbenz...
A pair of molecules 6-benzyl-4-methyl-2-phenylbenzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidine (14a), linked interconnected by hydrophobic bonds. Figure 4: A pair of molecules 6-benzyl-4-methyl-2-phenylbenz...
2D NOESY NMR spectrum of compound 18. Figure 5: 2D NOESY NMR spectrum of compound 18....
Molecule of compound 18 with arbitrary numbering of atoms. Ellipsoids of anisotropic thermal vibrations are depicted with 50% probability. Figure 6: Molecule of compound 18 with arbitrary numbering o...
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References

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